Danese had a major role in three of the six Columbo episodes in which she appeared. These include the 1976 Columbo movie Fade in to Murder, 1978's Murder Under Glass, 1989's Murder, a Self Portrait, 1991's Columbo and the Murder of a Rock Star, 1994's Columbo: Undercover and, lastly in 1997, Columbo: A Trace of Murder. She was never the killer, but she helped plan the murder in the episode A Trace of Murder - 25th Anniversary Movie. She has the distinction of having acted in more episodes of Columbo than any other Actress (but not actor).

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